Inflammation, oxidative stress, DNA damage response and epigenetic modifications interact behind the beneficial actions of melatonin on H. pylori-mediated gastric disorders

EFFECTS OF INFLAMMATION AND H. PYLORI INFECTION ON EXPRESSION OF CD44 VARIANT EXONS IN GASTRIC TISSUE

Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis

Helicobacter pylori (H. pylori) is a Gram negative bacterium that colonizes the stomach of almost half human population. It has evolved to escape immune surveillance, establishes lifelong inflammation, predisposing to genomic instability and DNA damage, notably double strand breaks. The epithelial host cell responds by activation of DNA damage repair (DDR) machinery that seems to be compromised...

The effect of pumpkin seed and endurance training on oxidative stress factors and DNA damage

Objective: This study aimed to investigate the effect of pumpkin seed and endurance training on oxidative stress factors and DNA damage of slow-twitch muscle tissue in male rats poisoned with hydrogen peroxide. Materials and Methods: A total of 48 adult male rats weighing 220±20 g at eight weeks were administered in accordance with stress interventions (hydrogen peroxide), pumpkin seed and end...

IL-1β (+3953 C/T) and IL-8 (-251 A/T) Gene Polymorphisms in H. pylori Mediated Gastric Disorders

Background: Previous studies imply that IL-1 and IL-8 gene variations may play a crucial role in the genetic predisposition to different gastric disorders upon H. pylori infection. Objective: The aim of this study was to determine the potential association between the prevalence of certain polymorphic sites and the risk of gastric disorders in Iranian population. Methods: One hundred and forty ...

Apple Peel Polyphenols and Their Beneficial Actions on Oxidative Stress and Inflammation

UNLABELLED Since gastrointestinal mucosa is constantly exposed to reactive oxygen species from various sources, the presence of antioxidants may contribute to the body's natural defenses against inflammatory diseases. HYPOTHESIS To define the polyphenols extracted from dried apple peels (DAPP) and determine their antioxidant and anti-inflammatory potential in the intestine. Caco-2/15 cells we...